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(名词解析)

发作性去极化漂移(PDS)

正确答案

在癫痫活动过程中,神经元的放电形式由单个动作电位转变为动作电位群的暴发,而且在暴发的头几个动作电位之后,膜的复极化过程趋缓,使神经元保持除极状态约100毫秒之久,这种现象称PDS。PDS为神经元的致痫活动性,通过突触联系和强直后易化作用,可诱发致痫灶外围及远处的神经元过度异常同步放电,导致癫痫的痫性发作。

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